Identification | More | [Name]
2-Chloro-N,N-dimethylacetamide | [CAS]
2675-89-0 | [Synonyms]
2-CHLORO-N,N-DIMETHYLACETAMIDE AKOS BBS-00000943 CHLOROACETYLDIMETHYLAMINE N,N-DIMETHYL-2-CHLOROACETAMIDE N,N-DIMETHYLCHLOROACETAMIDE N,N-DIMETHYLCHOROACETAMIDE 2-Chloro-N,N-Dimethyl Butylamine 2-CHLORO-N,N-DIMETHYL ACETAMINE Acetamide, 2-chloro-N,N-dimethyl- 2-CHLORO-N N-DIMETHYLACETAMIDE 98 % | [EINECS(EC#)]
220-224-4 | [Molecular Formula]
C4H8ClNO | [MDL Number]
MFCD00039360 | [Molecular Weight]
121.57 | [MOL File]
2675-89-0.mol |
Chemical Properties | Back Directory | [Melting point ]
15-16 °C | [Boiling point ]
98-100°C/11mm | [density ]
1.182 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.479
| [Fp ]
98-100°C/11mm | [storage temp. ]
Store below +30°C. | [solubility ]
Chloroform (Slightly), Hexane (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
-0.95±0.70(Predicted) | [color ]
Clear colorless to pale yellow | [BRN ]
969568 | [InChIKey]
XBPPLECAZBTMMK-UHFFFAOYSA-N | [CAS DataBase Reference]
2675-89-0(CAS DataBase Reference) |
Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R22:Harmful if swallowed. R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 3
| [WGK Germany ]
3
| [HS Code ]
29241990 |
Hazard Information | Back Directory | [Uses]
2-Chloro-N,N-dimethylacetamide is N,M-dialkyl amide used as an organic catalyst in the preparation of phosphorylated thiosemicarbazide. | [Synthesis]
In a 500 mL four-necked flask, sodium hydrogen carbonate 126.0 g (1.50 mol) and 146.8 g of toluene were added, and the mixture was stirred while cooling. The internal temperature was maintained below 5 ° C, 112.9 g (1.00 mol) of chloroacetyl chloride was added dropwise over 4 hours, and 49.6 g (1.10 mol) of dimethylamine gas was blown over 4 hours. After stirring at -2 to 1 ° C. for 1 hour, the reaction solution was filtrated under reduced pressure to remove inorganic salt crystals by filtration. The crystals were washed with 100 g of toluene, and the filtrate and washings were combined. After separating and removing the aqueous layer in the filtrate washings, the toluene layer was concentrated under reduced pressure to obtain 113.2 g (0.93 mol) of oily 2-chloro-N, N-dimethylacetamide. The yield was 93.1%.
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