| Identification | More | [Name]
4'-HYDROXYCHALCONE | [CAS]
2657-25-2 | [Synonyms]
2-BENZAL-4'-HYDROXYACETOPHENONE
2-BENZYLIDENE-4'-HYDROXYACETOPHENONE
4'-HYDROXYCHALCONE
BENZYLIDENE-(4-HYDROXYACETOPHENONE)
BENZYLIDENE-4'-HYDROXYACETOPHENONE
HYDROXYCHALCONE, 4'-
4'-Hydroxychalcone,97%
4'-Hydroxychalcone 98%
HYDROXYCHALCONE, 4-(RG)
4'-Hydroxychalcone98%
1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one
1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one | [Molecular Formula]
C15H12O2 | [MDL Number]
MFCD00016484 | [Molecular Weight]
224.25 | [MOL File]
2657-25-2.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow-cream powder | [Melting point ]
174-178 °C
| [Boiling point ]
419.6±45.0 °C(Predicted) | [density ]
1.191±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml | [form ]
powder to crystal | [pka]
7.72±0.15(Predicted) | [color ]
Light orange to Yellow to Green | [BRN ]
2049150 | [InChIKey]
UAHGNXFYLAJDIN-IZZDOVSWSA-N | [LogP]
3.650 (est) | [CAS DataBase Reference]
2657-25-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [HS Code ]
29145090 |
| Hazard Information | Back Directory | [Description]
4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6.1 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner.2 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.3 | [Chemical Properties]
yellow-cream powder | [Uses]
antineoplastic, | [Definition]
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'. | [storage]
4°C, protect from light |
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