| Identification | More | [Name]
(1R)-(-)-Menthyl acetate | [CAS]
2623-23-6 | [Synonyms]
(-)-(1R)-MENTHYL ACETATE
(1R)-(-)-MENTHYL ACETATE
(-)-ACETOXY-P-MENTHANE
FEMA 2668
L-MENTHYL ACETATE
(-)-MENTHYL ACETATE
MENTHYL ACETATE
MENTHYL ACETATE, L-
(R)-(-)-MENTHYL ACETATE
2-isopropyl-5-methyl-,acetate,l-cyclohexan-1-o
5-methyl-2-(1-methylethyl)-,acetate,[1R-(1.alpha.,2.beta.,5.alpha.)]-Cyclohexanol
acetate,(1r,3r,4s)-(-)-mentho
aceticacid(1R)-menthylester
cyclohexanol,5-methyl-2-(1-methylethyl)-,acetate,(1r-(1alpha,2beta,5alpha)
cyclohexanol,5-methyl-2-(1-methylethyl)-,acetate,[1theta-(1alpha,2beta,5
l-p-menth-3-ylacetate
p-menth-3-ylester,l-aceticaci
Acetoxymenthane
L-MENTHYL ACETATE 98+% NATURAL FCC
(-)-(1R)-MENTHYL ACETATE, TERPENE STANDA RD | [EINECS(EC#)]
220-076-0 | [Molecular Formula]
C12H22O2 | [MDL Number]
MFCD00001482 | [Molecular Weight]
198.3 | [MOL File]
2623-23-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
<25 °C | [alpha ]
-81°(20/D, c=8, C6H6) | [Boiling point ]
229-230 °C(lit.)
| [density ]
0.92 g/mL at 25 °C(lit.)
| [vapor pressure ]
45Pa at 20℃ | [FEMA ]
2668 | [refractive index ]
n20/D 1.447(lit.)
| [Fp ]
171 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
neat | [color ]
Colourless | [Specific Gravity]
0.922 | [Odor]
at 100.00 %. mentholic minty herbal tea fruity woody floral earthy | [Odor Type]
mentholic | [optical activity]
[α]20/D 81°, c = 8 in benzene | [Water Solubility ]
23.2mg/L at 20℃ | [JECFA Number]
431 | [Merck ]
14,5839 | [BRN ]
2208505 | [LogP]
4.39 at 25℃ | [CAS DataBase Reference]
2623-23-6(CAS DataBase Reference) | [EPA Substance Registry System]
2623-23-6(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
NA 1993 / PGIII | [WGK Germany ]
3
| [RTECS ]
AI5900000
| [TSCA ]
Yes | [HS Code ]
2915 39 00 | [Safety Profile]
Low toxicity by
ingestion and skin contact. A skin irritant.
When heated to decomposition it emits
acrid smoke and irritating fumes. | [Toxicity]
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
(1R)-(-)-Menthyl acetate occurs in peppermint oils. It is a colorless liquid with a fresh, fruity,
peppermint odor.
(?)-Menthyl acetate is prepared by acetylation of (?)-menthol (e.g., with acetic
anhydride). It is used mainly in peppermint flavors and reconstituted peppermint
oils, but also to a small extent in perfumery. | [Uses]
L-Menthyl Acetate, and its derivatives, is used as a penetration enhancers, to enhance the skin permeation of various drugs with differing lipophilicities, such as 5-aminolevulinic acid (ALA), 5-fluorouracil (5-FU), isosorbide dinitrate (ISDN), lidocaine (LD), etc. | [Definition]
ChEBI: (-)-Menthyl acetate is a p-menthane monoterpenoid. | [Flammability and Explosibility]
Notclassified | [Biochem/physiol Actions]
Taste at 25 ppm | [Synthesis]
L-Menthyl acetate is produced by direct esterification of racemicMenthol with Acetic acid under azeotropic
conditions. |
|
|