| Identification | Back Directory | [Name]
N3-PEG3-tBu | [CAS]
252881-73-5 | [Synonyms]
N3-PEG3-tBu
252881-73-5
Azido-PEG3-COOtBu
N3-PEG3-CH2CH2-Boc
N3-PEG3-CH2CH2COOtBu
N3-?PEG3-?t-?butyl ester
tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate
N3-PEG3-CH2CH2COOtBu
3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester | [Molecular Formula]
C13H25N3O5 | [MDL Number]
MFCD22201543 | [MOL File]
252881-73-5.mol | [Molecular Weight]
303.355 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-t-butyl ester is a click chemistry reagent. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Azido-PEG3-t-butyl Ester is used as a linker in the conjugation of peptides. | [Biological Activity]
N3-PEG3-tBu is a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). It is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| PEGs | Alkyl/ether | Cleavable | |
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