| Identification | Back Directory | [Name]
PHYSALAEMIN | [CAS]
2507-24-6 | [Synonyms]
FI 6422
Physalemin
PHYSALAEMIN
Physalaemine
PHYSALAEMIN ACOH 3H2O
Physalemin(7CI,8CI,9CI)
Physalaemin, ≥97% (HPLC)
PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2
PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O
L-pGlu-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
5-Oxo-L-Pro-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
L-Methioninamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl- | [Molecular Formula]
C58H84N14O16S | [MDL Number]
MFCD00076375 | [MOL File]
2507-24-6.mol | [Molecular Weight]
1265.44 |
| Hazard Information | Back Directory | [Description]
Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects. | [Uses]
Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.? | [Biological Activity]
Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor. | [in vitro]
Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a). | [target]
Neurokinin-1 (NK1) receptor | [References]
[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457 |
|
|