| Identification | More | [Name]
Glyphosine | [CAS]
2439-99-8 | [Synonyms]
GLYCINE-N,N-BIS(METHYLENEPHOSPHONIC ACID)
GLYPHOSINE
N-(CARBOXYMETHYL)IMINODI(METHYLPHOSPHINIC ACID)
N,N-BIS(PHOSPHONOMETHYL)GLYCINE
cp41845
n,n-bis(phosphonomethyl)-glycin
Polaris(monsanto)
Glyphosphine
polaris
N,N-bis phophonomethyl glycine
glyphosine (ISO) N,N-bis(phosphonomethyl)glycine
2-(Bis(phosphonomethyl)amino)acetic acid
N,N-Di(phosphonomethyl)glycine
Nitrilomonomethylcarbonyldimethylphosphonic acid | [EINECS(EC#)]
219-468-4 | [Molecular Formula]
C4H11NO8P2 | [MDL Number]
MFCD00056670 | [Molecular Weight]
263.08 | [MOL File]
2439-99-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
263°C | [Boiling point ]
668.4±65.0 °C(Predicted) | [density ]
1.952±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
PBS (pH: 7.2):5.0(Max Conc. mg/mL);19.01(Max Conc. mM) | [form ]
Solid | [pka]
pK1 1.42; pK2 2.10; pK3 5.02; pK4 6.40; pK5 11.19(at 25℃) | [color ]
White | [Water Solubility ]
248g/L(20 ºC) | [Merck ]
13,4526 | [BRN ]
1884944 | [CAS DataBase Reference]
2439-99-8(CAS DataBase Reference) | [EPA Substance Registry System]
2439-99-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S2:Keep out of the reach of children . | [RIDADR ]
UN 3261 8/PG 3
| [WGK Germany ]
1
| [RTECS ]
MB9120000
| [HS Code ]
2922.49.8000 | [Toxicity]
LD50 orally in rats: 3925 mg/kg; dermally in rabbits: >5010 mg/kg (Ahlrichs) |
| Hazard Information | Back Directory | [Description]
Glyphosine was introduced in 1973 and is preferably used in sugar beets. The synthesis starting with glycine uses two equivalents of formaldehyde and of phosphorous trichloride under oxidative conditions. A second derivative of Glyphosate is a cyclic phosphaoxazole being formed from Glyphosate and formaldehyde. This compound is claimed to control the growth of some grasses without dis- coloration or phytotoxicity.
| [Uses]
Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89
Anti-diabetic; delay onset of diabetes in non-obese NOD mice
Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.? | [Uses]
Chemical ripener; plant growth regulator. | [Definition]
ChEBI: A tertiary amino compound that consists of glycine bearing two N-phosphonomethyl substituents. | [General Description]
N,N-Bis(phosphonomethyl)glycine was present in the ligand bound to human apotransferrin. | [Biochem/physiol Actions]
Anti-diabetic; delay onset of diabetes in non-obese NOD mice |
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