| Identification | Back Directory | [Name]
VH032-C3-NH2 | [CAS]
2361119-88-0 | [Synonyms]
VH032-C3-NH2
VH032-C3-NH2((S,R,S)-AHPC-C3-NH2) | [Molecular Formula]
C26H37N5O4S | [MDL Number]
MFCD33029228 | [MOL File]
2361119-88-0.mol | [Molecular Weight]
515.67 |
| Hazard Information | Back Directory | [Uses]
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1]. | [IC 50]
VHL | [References]
[1] Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. DOI:10.1016/j.chembiol.2019.11.006 |
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