| Identification | Back Directory | [Name]
N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine | [CAS]
232271-19-1 | [Synonyms]
MDK1191
MDK-1191
TR 14035
TR-14035;TR 14035;TR14035
TR 14035;TR14035;MDK-1191;MDK1191
N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine
(S)-2-(2,6-DichlorobenzaMido)-3-(2',6'-diMethoxy-[1,1'-biphenyl]-4-yl)propanoic acid
[1,1'-Biphenyl]-4-propanoic acid, α-[(2,6-dichlorobenzoyl)amino]-2',6'-dimethoxy-, (αS)-
(alphaS)-alpha-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy-[1,1'-biphenyl]-4-propanoic acid | [Molecular Formula]
C24H21Cl2NO5 | [MDL Number]
MFCD09970400 | [MOL File]
232271-19-1.mol | [Molecular Weight]
474.33 |
| Chemical Properties | Back Directory | [Boiling point ]
604.0±55.0 °C(Predicted) | [density ]
1.333 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: ≥ 41 mg/mL (86.44 mM) | [form ]
Powder | [pka]
3.53±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
TR-14035 (SB 683698, MDK-1191) is a dual alpha4beta (α4β) integrin antagonist with IC50 values of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively. | [in vitro]
TR-14035 blocks adhesion of RPMI-8866 cells to MAdCAM-Ig by 100% at 1 μM, with an approximate IC 50 of 0.01 μM.
| [target]
| Target | Value | α4β7
(Cell-free assay) | 7 nM | α4β1
(Cell-free assay) | 87 nM |
| [storage]
Store at -20°C |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
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