| Identification | More | [Name]
Oxymetazoline hydrochloride | [CAS]
2315-02-8 | [Synonyms]
2-[3-HYDROXY-2,6-DIMETHYL-4-T-BUTYL-BENZYL]-2-IMIDAZOLINE
2-[3-HYDROXY-2,6-DIMETHYL-4-T-BUTYLBENZYL]-2-IMIDAZOLINE HYDROCHLORIDE
3-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYLPHENOL, HCL
3-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYL-PHENOL HYDROCHLORIDE
AKOS 92115
OXYMETAZOLINE HCL
OXYMETAZOLINE HYDROCHLORIDE
2-(4-t-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride
2,6-dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochlori
6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenohydrochloride
6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenolhydrochloride
afrazine
afrinhydrochloride
duration
iliadinhydrochloride
nafrinehydrochloride
neonabel
oxymetazolinechloride
OXYMETAZOLINE HYDROCHLORIDE, USP STANDARD
OXYMETAZOLINE HYDROCHLORIDE, MM(CRM STANDARD) | [EINECS(EC#)]
219-015-0 | [Molecular Formula]
C16H25ClN2O | [MDL Number]
MFCD00797520 | [Molecular Weight]
296.84 | [MOL File]
2315-02-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R28:Very Toxic if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
SK1225000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [HS Code ]
2933290000 | [Toxicity]
LD50 orally in mice: 10 mg/kg (Hotovy) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Originator]
Nasivin,Merck,W. Germany ,1961 | [Uses]
muscle relaxant (smooth), cerebral vasodilator | [Uses]
Oxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.
| [Uses]
Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin. | [Definition]
ChEBI: A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal con
estion. | [Manufacturing Process]
10 grams 2,6-dimethyl-3-hydroxy-4-tertiary butylbenzylcyanide (produced by chloromethylation of 2,4-dimethyl-6-tertiary butyl-phenol with formaldehyde and HCl and conversion of the substituted benzyl chloride with NaCN; crystals, from alcohol, melting at 135° to 137°C) and 10.7 grams ethylenediaminemono-p-toluenesulfonate are heated in an oil bath to approximately 235°C for 1? hours, whereby ammonia is evolved. The free base is obtained from the p-toluene-sulfonic acid imidazoline salt which is difficultly soluble in water, by conversion with 50 cc of a 10% NaOH solution. Said base is recrystallized from benzene, and 7.5 grams (62% of the theoretical yield) 2-(2',6'-dimethyl3'-hydroxy-4'-tertiary butylbenzyl)-2-imidazoline, MP 180° to 182°C, are obtained.
By dissolving the free base in an ethyl alcohol solution of hydrochloric acid and adding ether, the hydrochloride can be produced in the usual manner. Said hydrochloride melts, when recrystallized from alcoholic ether, at 300° to 303°C and is decomposed | [Brand name]
Ocuclear (Schering-Plough); Visine (Pfizer). | [Therapeutic Function]
Nasal decongestant | [Biological Activity]
Partial α 2A adrenoceptor agonist and α 1A agonist. Agonist/antagonist activity at 5-HT receptors. |
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