| Identification | More | [Name]
2-Bromo-4-chloropyridine | [CAS]
22918-01-0 | [Synonyms]
2-BROMO-4-CHLOROPYRIDINE
4-CHLORO-2-BROMOPYRIDINE | [Molecular Formula]
C5H3BrClN | [MDL Number]
MFCD03840757 | [Molecular Weight]
192.44 | [MOL File]
22918-01-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow liquid | [Melting point ]
<30℃ | [Boiling point ]
98°C | [density ]
1.736±0.06 g/cm3(Predicted) | [Fp ]
>110℃ | [storage temp. ]
-20°C | [solubility ]
soluble in Methanol | [form ]
powder to lump to clear liquid | [pka]
0.12±0.10(Predicted) | [color ]
White or Colorless to Almost white or Almost colorless | [InChIKey]
SURKZMFXICWLHU-UHFFFAOYSA-N | [CAS DataBase Reference]
22918-01-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
1 | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow liquid | [Synthesis]
To an aqueous solution of 48 % strength hydrobromic acid (82 rnL) at 0 0C was added 4-chloro-2-pyridinamine (8.9 g, 69.2 mmol) followed by addition of bromine (33.4 g, 209 mmol) over 10 min. The resulting mixture was cooled to -10 0C, and a solution of NaNO2 (10.65 g, 154 mmol) in H2O (20 rnL) was poured over 30 min. The mixture was warmed at room temperature and stirred overnight. The mixture was cooled to 0 0C, and NaOH (35 %) was added until the pH >10. The mixture was then extracted with ethyl acetate. The organic layer was then dried, filtered, and concentrated in vacuo. The product was purified via column chromatography (0-20 per cent ethyl acetate/hexane) to afford 2-bromo-4-chloropyridine (12.1 g, 92 %). |
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