| Identification | More | [Name]
D(-)-4-Hydroxyphenylglycine | [CAS]
22818-40-2 | [Synonyms]
4-HYDROXY-D-PHENYLGLYCINE
D-(-)-2-(4-HYDROXYPHENYL)GLYCINE
D(-)-2-(P-HYDROXYPHENYL)GLYCINE
D-4-HYDROXYPHENYLGLICYNE
D-(-)-4-HYDROXYPHENYLGLYCINE
D-4-HYDROXYPHENYLGLYCINE
D-(-)-A-4-HYDROXYPHENYLGLYCINE
(D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE
D-ALPHA-PARA-HYDROXYPHENYLGLYCINE
D(-)PARA-HYDROXY-PHENYLGLYCINE
D-(-)-P-HYDROXYPHENYLGLYCINE
D-P-HYDROXYPHENYLGLYCINE
H-D-HPG-OH
H-D-PHG(4-HYDROXY)-OH
H-D-PHG(4-OH)-OH
HYDROXY PHENYL GLYCINE
(R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE
(R)-4-HYDROXYPHENYLGLYCINE
(r)-alpha-amino-4-hydroxybenzeneacetic acid
(R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID | [EINECS(EC#)]
245-247-7 | [Molecular Formula]
C8H9NO3 | [MDL Number]
MFCD00004262 | [Molecular Weight]
167.16 | [MOL File]
22818-40-2.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white powder | [Melting point ]
240 °C (dec.)(lit.)
| [alpha ]
-156 º (c=1, 1 N HCl) | [Boiling point ]
295.73°C (rough estimate) | [density ]
1.396 | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
-158 ° (C=1, 1mol/L HCl) | [storage temp. ]
2-8°C | [solubility ]
5g/l | [form ]
Liquid | [pka]
2.15±0.10(Predicted) | [color ]
Clear colorless to yellow | [optical activity]
[α]23/D 158±3°, c = 1 in 1 M HCl | [Water Solubility ]
5 g/L (20 ºC) | [BRN ]
2210998 | [LogP]
-2.25 | [CAS DataBase Reference]
22818-40-2(CAS DataBase Reference) | [EPA Substance Registry System]
22818-40-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29225000 |
| Hazard Information | Back Directory | [Description]
d-(p-Hydroxyphenyl)glycine (d-HPG) is
widely used in large amounts as an important
intermediate for the synthesis of amoxicillin and
several other semisynthetic β-lactam antibiotics. | [Chemical Properties]
off-white powder | [Uses]
4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics. | [Definition]
ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus. | [Flammability and Explosibility]
Nonflammable | [reaction suitability]
reaction type: solution phase peptide synthesis | [Purification Methods]
Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.] |
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