| Identification | Back Directory | [Name]
PROTAC MDM2 Degrader-1 | [CAS]
2249944-98-5 | [Synonyms]
PROTAC MDM2 Degrader-1
1-Piperazineacetamide, N,N'-[oxybis(2,1-ethanediyloxy-3,1-propanediyl)]bis[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-, rel- | [Molecular Formula]
C74H84Cl4N10O13 | [MDL Number]
MFCD32197288 | [MOL File]
2249944-98-5.mol | [Molecular Weight]
1463.33 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.46±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836); Black: Linker (HY-128844); Blue: E3 ligase Ligand 15 (HY-128836))[1] | [IC 50]
MDM2 | [References]
[1] Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A. |
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