| Identification | Back Directory | [Name]
PROTAC RIPK degrader-2 | [CAS]
1801547-16-9 | [Synonyms]
PROTAC_RIPK2
PROTAC RIPK degrader-2 | [Molecular Formula]
C52H65N7O11S3 | [MDL Number]
MFCD32263376 | [MOL File]
1801547-16-9.mol | [Molecular Weight]
1060.31 |
| Chemical Properties | Back Directory | [Boiling point ]
1196.5±65.0 °C(Predicted) | [density ]
1.315±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PROTAC RIPK degraders -2 is a non-peptide PROTAC based on von Hippel-Lindau and targets serine-threonine kinase RIPK2, which is highly selective to the degradation of RIPK2. PROTAC RIPK degrader-2 acts as an activator to increase cell death and activate ion channels in cancer cells. PROTAC RIPK degrader-2 also can inhibit protein interactions, such as receptors and ligands, involved in a variety of diseases, such as cancer and diabetes[1][2]. | [IC 50]
RIPK2; VHL | [References]
[1] Bondeson DP, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug;11(8):611-7. DOI:10.1038/nchembio.1858
[2] Wang C, et al. VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives. Eur J Med Chem. 2022 Jan 5;227:113906. DOI:10.1016/j.ejmech.2021.113906 |
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| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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