| Identification | More | [Name]
2-(Di-tert-butylphosphino)biphenyl | [CAS]
224311-51-7 | [Synonyms]
(2-biphenyl)di-tert-butylphosphine
(2-BIPHENYLYL)DI-TERT-BUTYLPHOSPHINE
2-(DI-T-BUTYLPHOSPHINO)BIPHENYL
2-(DI-TERT-BUTYLPHOSPHINO)BIPHENYL
BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE
2-(Di-t-butylphosphino)biphenyl,99%JohnPhos
2-(Di-t-butylphosphine) biphenyl
PHOSPHINE, [1,1''-BIPHENYL]-2-YLBIS(1,1-DIMETHYLETHYL)-
JohnPhos
2-(Di-tert-butylphosphino)-biphenyl, JohnPhos
(2-Biphenylyl)di-tert-butylphosphine, 2-(Di-tert-butylphosphino)biphenyl, JohnPhos | [EINECS(EC#)]
607-074-9 | [Molecular Formula]
C20H27P | [MDL Number]
MFCD01862440 | [Molecular Weight]
298.4 | [MOL File]
224311-51-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
86-88 °C (lit.) | [Boiling point ]
405.5±24.0 °C(Predicted) | [density ]
1 g/cm3 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonicated) | [form ]
Crystals or Crystalline Powder | [color ]
White | [Water Solubility ]
Insoluble | [BRN ]
8322131 | [Stability:]
Air Sensitive | [InChI]
InChI=1S/C20H27P/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16/h7-15H,1-6H3 | [InChIKey]
CNXMDTWQWLGCPE-UHFFFAOYSA-N | [SMILES]
P(C1=CC=CC=C1C1=CC=CC=C1)(C(C)(C)C)C(C)(C)C | [CAS DataBase Reference]
224311-51-7(CAS DataBase Reference) | [Storage Precautions]
Store under inert gas;Air sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust . | [WGK Germany ]
3
| [F ]
10-23 | [TSCA ]
No | [HazardClass ]
AIR SENSITIVE | [HS Code ]
29029090 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
suzuki reaction | [General Description]
JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy. |
| Questions And Answer | Back Directory | [Reactions]
- Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
- Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
- Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides.
- Effective ligand used in palladium-catalyzed arylation of thiazoles.
- Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation.
- Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.
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