| Identification | Back Directory | [Name]
SiraMesine, Lu-28-179 | [CAS]
224177-60-0 | [Synonyms]
Siramesine.HCl
SiraMesine, Lu-28-179
Lu 28-179 hydrochlorid
LU 28-179 HYDROCHLORIDE
SiraMesine (hydrochloride)
Siramesine, Lu-28-179 HCl
Siramesine hydrochloride, >=98%
Siramesine (HCl salt), Lu-28-179
SiramesineLu-28-179 hydrochloride
1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]-3H-spiro[isobenzofuran-1,4'-piperidine] Hydrochloride
1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
Siramesine hydrochloride 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride
SiraMesine, Lu-28-179 1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]butyl]spiro[isobenzofuran-1(3H),4'-piperidine] monohydrochloride | [Molecular Formula]
C30H32ClFN2O | [MDL Number]
MFCD28144522 | [MOL File]
224177-60-0.mol | [Molecular Weight]
491.039 |
| Chemical Properties | Back Directory | [Melting point ]
225 °C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
>49.1mg/mL in DMSO | [form ]
powder to crystal | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Uses]
Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3]. | [IC 50]
Sigma 1 Receptor | [storage]
Desiccate at -20°C |
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