| Identification | Back Directory | [Name]
HOOCCH2CH2O-PEG10-CH2CH2COOH | [CAS]
2097010-30-3 | [Synonyms]
HOOCCH2CH2-PEG10-CH2CH2COOH
HOOCCH2CH2O-PEG10-CH2CH2COOH
4,7,10,13,16,19,22,25,28,31,34-Undecaoxaheptatriacontanedioic acid | [Molecular Formula]
C26H50O15 | [MDL Number]
MFCD28385481 | [MOL File]
2097010-30-3.mol | [Molecular Weight]
602.67 |
| Hazard Information | Back Directory | [Biological Activity]
Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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