| Identification | Back Directory | [Name]
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride | [CAS]
209481-24-3 | [Synonyms]
SB 271046A
SB 271046A; SB-271046A
SB-271046A >=98% (HPLC)
4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide
5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-, Monohydrochloride | [Molecular Formula]
C20H22ClN3O3S2.HCl | [MDL Number]
MFCD10565914 | [MOL File]
209481-24-3.mol | [Molecular Weight]
488.451 |
| Hazard Information | Back Directory | [Uses]
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide Hydrochloride is a 5-Hydroxytryptamine6 receptor antagonist. | [Biological Activity]
The first potent and selective 5-HT6 antagonist. Training in cognitive tasksas well as administration SB-271046induces an increase in pERK1/2 and pCREB1 levelswhile CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2not pCREB1/2. SB-271046 reverses MK-801-inducedbut not scopolamine-inducedlearning impairments. Howeverwith coadministration of galanthamineboth types of learning impairments were ameliorated. | [storage]
Desiccate at RT |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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