| Identification | More | [Name]
Oxytetracycline hydrochloride | [CAS]
2058-46-0 | [Synonyms]
[4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
5-hydroxytetracycline hydrochloride
AQUACYCLINE
BIO-MYCIN
GEOMYCIN
OTC
OXYTETRACYCLINE HCL
OXYTETRACYCLINE HYDROCHLORIDE
TETRAMYCIN
TOXINAL
10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-monohydrochloride
2-naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,
5alpha,5aalpha,6beta,12aalpha)]-aalph
6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,[4s-(4alpha,4
biosolvomycin
engemycin
hydrocyclin
liquamycininjectable
mepatar
nsc9169 | [EINECS(EC#)]
218-161-2 | [Molecular Formula]
C22H25ClN2O9 | [MDL Number]
MFCD00135815 | [Molecular Weight]
496.89 | [MOL File]
2058-46-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
180°C | [alpha ]
-188～-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis) | [storage temp. ]
0-6°C | [solubility ]
Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline. | [form ]
crystalline
| [color ]
yellow
| [PH]
2.0～3.0 (10g/l, 25℃) | [optical activity]
[α]/D -190 to -200°, c =1 in 0.1 M HCl (anhydrous basis) | [Water Solubility ]
>100 g/L | [Sensitive ]
Light Sensitive | [Usage]
Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial | [λmax]
360nm(H2O)(lit.) | [Merck ]
13,7046 | [BRN ]
3853107 | [Stability:]
Hygroscopic | [CAS DataBase Reference]
2058-46-0(CAS DataBase Reference) | [EPA Substance Registry System]
2058-46-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R63:Possible risk of harm to the unborn child.
R36:Irritating to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
QI8225000
| [F ]
8-10-23 | [TSCA ]
Yes | [HS Code ]
29413000 | [Toxicity]
LD50 oral in mouse: 6696mg/kg |
| Hazard Information | Back Directory | [General Description]
Odorless fluffy yellow solid or yellow powder. Bitter taste. | [Reactivity Profile]
OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) is sensitive to light. OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) may be unstable at temperatures above 77° F. OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. This chemical undergoes hydrolysis in the presence of water. OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) may be incompatible with alkalis. | [Air & Water Reactions]
This chemical is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing. | [Fire Hazard]
Flash point data for this chemical are not available. OXYTETRACYCLINE HYDROCHLORIDE is probably combustible. | [Description]
Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates. | [Chemical Properties]
Yellow Crystalline Solid | [Originator]
Terramycin,Pfizer,US,1950 | [Uses]
Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial | [Uses]
Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. | [Definition]
ChEBI: Oxytetracycline hydrochloride is an organic molecular entity. | [Manufacturing Process]
The pH was adjusted to 7.0 with sodium hydroxide and calcium carbonate was added at the rate of 1 g/l.
500 ml portions of the above medium were added to Fernbach flasks which
were then sterilized at 121°C for 30 minutes. Upon cooling, the flasks were inoculated with a suspension of the growth of s. rimosus obtained from the surface of beef lactose agar slants, and the flasks were shaken for 4 days at 28°C on a rotary shaker having a displacement of 2" at an rpm of 200. At the end of this period the broth was found to contain 640 C.D.U/ml and 400 chloramphenicol units/ml. The mycelium was separated from the broth by filtration and the latter was adjusted to pH 9.0. The antibiotic was extracted from the broth with n-butanol, and when the ultraviolet absorption spectrum was observed on the butanol solution of the antibiotic, peaks in the absorption curve were found at 385 and 270 millimicrons.
| [Brand name]
Terramycin (Pfizer). | [Therapeutic Function]
Antibiotic |
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