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ChemicalBook--->CAS DataBase List--->2031177-48-5

2031177-48-5

2031177-48-5 Structure

2031177-48-5 Structure
IdentificationBack Directory
[Name]

ZM223
[CAS]

2031177-48-5
[Synonyms]

ZM223
ZM223;ZM-223;ZM 223
Benzamide, N-[6-[[2-[(4-aminophenyl)thio]acetyl]amino]-2-benzothiazolyl]-4-(trifluoromethyl)-
[Molecular Formula]

C23H17F3N4O2S2
[MDL Number]

MFCD31813604
[MOL File]

2031177-48-5.mol
[Molecular Weight]

502.53
Chemical PropertiesBack Directory
[density ]

1.51±0.1 g/cm3(Predicted)
[pka]

8.23±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active[1].
[References]

[1] Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183. DOI:10.1016/j.ejmech.2017.03.076
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