| Identification | More | [Name]
(S)-(+)-2-Amino-3-methyl-1-butanol | [CAS]
2026-48-4 | [Synonyms]
(2S)-2-AMINO-3-METHYL-BUTAN-1-OL
H-L-VAL-OL
H-VALINOL
H-VAL-OL
L-2-AMINO-3-METHYL-1-BUTANOL
l-2-amino-3-methylbutan-1-ol
L-VALINAL
(+)-L-VALINOL
L-(+)-VALINOL
L-VALINOL
(S)-(+)-2-AMINO-3-METHYL-1-BUTANOL
(S)-2-AMINO-3-METHYL-1-BUTANOL
S-(-)-2-AMINO-3-METHYL-1-BUTANOL
(S)-2-AMINO-3-METHYL-BUTAN-1-OL
(S)-(+)-2-AMINO-3-METHYL-BUTANOL
(S)-2-AMINO-3-METHYL-L-BUTANOL
S-VALINOL
1-Butanol, 2-amino-3-methyl-, (S)-
(S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol
Valinol,97% | [EINECS(EC#)]
217-975-5 | [Molecular Formula]
C5H13NO | [MDL Number]
MFCD00064296 | [Molecular Weight]
103.16 | [MOL File]
2026-48-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
30-34 °C
| [alpha ]
16 º (c=10,EtOH) | [Boiling point ]
81 °C8 mm Hg(lit.)
| [density ]
0.926 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4548(lit.)
| [Fp ]
196 °F
| [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Liquid After Melting | [pka]
12.82±0.10(Predicted) | [color ]
Clear slightly yellow | [optical activity]
[α]25/D +10°, c = 10 in H2O | [Water Solubility ]
Soluble in water. | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
1719137 | [InChIKey]
NWYYWIJOWOLJNR-RXMQYKEDSA-N | [CAS DataBase Reference]
2026-48-4(CAS DataBase Reference) | [NIST Chemistry Reference]
(S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4) | [Storage Precautions]
Store under nitrogen;Air sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-23 | [HazardClass ]
IRRITANT | [HS Code ]
29221980 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer. | [Purification Methods]
Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.] |
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