| Identification | Back Directory | [Name]
JAK3 INHIBITOR I | [CAS]
202475-60-3 | [Synonyms]
Janex 1
CS-2623
WHI-P131
WHI-P131, >98%
JANEX-1;WHI-P131
JAK3 INHIBITOR I
WHI-P131(Janex 1)
A JAK3 inhibitor
WHI-P131
WHIP-131;JANEX-1);WHIP131;JANEX1
4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
Phenol, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-
4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE | [Molecular Formula]
C16H15N3O3 | [MDL Number]
MFCD01862614 | [MOL File]
202475-60-3.mol | [Molecular Weight]
297.31 |
| Chemical Properties | Back Directory | [Boiling point ]
468.1±40.0 °C(Predicted) | [density ]
1.336±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO: 18 mg/mL, soluble
| [form ]
solid
| [pka]
10.06±0.26(Predicted) | [color ]
yellow
| [Stability:]
Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5 | [Uses]
Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability. | [References]
1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463
2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22
3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213
4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287
5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23 |
|
| Company Name: |
China Langchem Inc.
|
| Tel: |
0086-21-58956006 |
| Website: |
m.is0513.com/ShowSupplierProductsList19141/0.htm |
|