成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->19982-08-2

19982-08-2

19982-08-2 Structure

19982-08-2 Structure
IdentificationMore
[Name]

Memantine
[CAS]

19982-08-2
[Synonyms]

AKOS BB-9600
AURORA KA-7643
MEMANTINE
TIMTEC-BB SBB002574
3,5-dimethyladamantan-1-amine HCl
1-Amino-3,5-dimethyladamantane
3,5-Dimethyl-1-aminoadamantane
3,5-DIMETHYL-1-AMINOADAMANTANE(MEMANTINE)
1,3-Dimethylaminoadamantane
3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
MEMENTINE HYDROCHHLORIDE
1-Adamantanamine, 3,5-dimethyl-
3,5-Dimethyltricyclo(3.3.1.1(sup 3,7))decan-1-amine
Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, 3,5-dimethyl-
[EINECS(EC#)]

690-724-9
[Molecular Formula]

C12H21N
[MDL Number]

MFCD02114015
[Molecular Weight]

179.3
[MOL File]

19982-08-2.mol
Chemical PropertiesBack Directory
[Melting point ]

258 °C
[Boiling point ]

239.8±8.0 °C(Predicted)
[density ]

1.046
[refractive index ]

nD25 1.4941
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[solubility ]

Chloroform (Slightly), DMSO (Slightly)
[form ]

Solid
[pka]

10.79±0.60(Predicted)
[color ]

Colorless Oil to Off-White Waxy
[CAS DataBase Reference]

19982-08-2(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
[Hazardous Substances Data]

19982-08-2(Hazardous Substances Data)
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1,3-Dimethylaminoadamantane(19982-08-2).msds
Hazard InformationBack Directory
[Description]

Memantine is a potent antagonist of the N-methyl-D-aspartate (NMDA) receptor. Experimentally, memantine inhibits and reverses the abnor-mal activity of a protein phosphatase (PP-2A) that leads to tauhyperphosphorylation and to neurofibrillary degeneration inAD. Memantine is effective and well toler-ated in patients with severe AD  and wasapproved by the FDA for the treatment of moderate-to-severe AD. 
[Originator]

Akatinol,Merz,W. Germany,1983
[Uses]

antiulcer
[Uses]

Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer''s disease and possibly vascular dementia (multi-infarct dementia). Memantine’s method of action involves an uncompetitive, low-affinity, open-channel blocker; it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission.
[Application]

Memantine has been used in patients with VaD basedon its experimental efficacy in animal models of ischaemiclesions.Memantine acts on potentially contributing factorssuch as neuronal depolarization,mitochondrial dysfunc-tion, magnesium effects on NMDA receptors and chronicglutamatergic overstimulation; it also has shown positiveeffects on long-term potentiation and cognitive tests in stan-dard animal models of impaired synaptic plasticity. 
[Definition]

ChEBI: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
[Manufacturing Process]

A mixture of 24 g of 1,3-dimethyladamantane and 80 ml of bromine was refluxed for 6 hours. The reaction product mixture was cooled, taken up in about 200 ml of chloroform, and poured onto ice. The excess bromine was removed by adding sodium hydrosulfite. The chloroform layer was separated from the aqueous layer, dried, concentrated in vacuo, and distilled at reduced pressure to yield 30.5 g of product having a boiling point of about 118°C at 5- 6 mm; nD25 = 1.5169-1.5182. The product was identified by nuclear magnetic resonance (NMR) and elemental analyses as 1-bromo-3,5- dimethyladamantane.
A mixture of 20 g of 1-bromo-3,5-dimethyladamantane, 75 ml of acetonitrile, and 150 ml of concentrated sulfuric acid was allowed to react overnight at ambient room temperature. The red reaction product mixture was poured over crushed ice, and the white solid which precipitated was taken up in benzene and the benzene solution dried over sodium hydroxide pellets. The benzene solution was filtered from the drying agent and evaporated to dryness in vacuo to yield 18.2 g of product having a melting point of about 97°C and identified by infrared spectrum as 1-scetamido-3,5-dimethyladamantane.
A mixture of 18 g of 1-acetamido-3,5-dimethyladamantane, 38 g of sodium hydroxide, and 300 ml of diethylene glycol was refluxed for a period of 6 hours. The reaction product mixture was cooled and poured onto about 2,000 ml of crushed ice. The basic solution thus obtained was extracted five times with 250 ml portions of benzene and the aqueous layer was discarded. The combined benzene extracts were dried over sodium hydroxide and the dried benzene solution concentrated in vacuo to give a crude oil weighing 14 g and having nD25 = 1.4941, A 4 g sample of the crude oil was dissolved in ether and the solution saturated with anhydrous hydrogen chloride. The solid which precipitated was filtered off and recrystallized from a mixture of alcohol and ether to yield product weighing 3.5 g and melting at 258°C.
It was identified by analysis as 1-amino-3,5-dimethyladamantane hydrochloride.
[Therapeutic Function]

Spasmolytic
[Biological Activity]

An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
[Clinical Use]

NMDA-receptor antagonist:
Treatment of moderate to severe dementia in Alzheimer’s disease
[Metabolism]

Molecular weight (daltons) 215.8 % Protein binding 45 % Excreted unchanged in urine 48 (74% plus metabolites) Volume of distribution (L/kg) 10 Half-life - normal/ESRF (hrs) 60-100 / 117-1561
Spectrum DetailBack Directory
[Spectrum Detail]

Memantine(19982-08-2)1HNMR
19982-08-2 suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-(0)57185586718 +86-13336195806 , +86-13336195806
Website: www.capot.com
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-371-66670886
Website: https://www.dakenchem.com/
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: SHANDONG ZHI SHANG CHEMICAL CO.LTD
Tel: +86 18953170293 , +86 18953170293
Website: https://www.zhishangchem.com/
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: m.is0513.com/ShowSupplierProductsList454175/0.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418671 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: Dorne Chemical Technology co. LTD
Tel: +86-86-13583358881 +8618560316533 , +8618560316533
Website: m.is0513.com/manufacturer/zibo-dorne-chemical-technology-403/
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Finetech Industry Limited
Tel: +86-27-87465837 +8618971612321 , +8618971612321
Website: https://www.finetechnology-ind.com/
Company Name: Henan Alfa Chemical Co., Ltd
Tel: +86-18339805032; +8618339805032 , +8618339805032
Website: http://m.is0513.com/manufacturer/henan-alfa-chemical-570/
Company Name: changzhou huayang technology co., ltd
Tel: +8615250961469 , +8615250961469
Website: http://www.huayangchem.com/template/eabout.html
Company Name: Wuhan Golt Biotech Co., Ltd.
Tel: +8615389281203 , +8615389281203
Website: www.goltbiotech.com
Tags:19982-08-2 Related Product Information
1861-32-1 1330-20-7 68-12-2 2155-94-4 768-94-5 102-70-5 77-78-1 616-38-6 106-20-7 74-84-0 131-11-3 67-68-5 103-49-1 102-71-6 115-10-6 624-49-7 98-94-2 112-18-5