| Identification | Back Directory | [Name]
4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | [CAS]
1957236-10-0 | [Synonyms]
Thalidomide-4-PEG3-NH2
Thalidomide-O-PEG2-amine
Thalidomide-O-PEG2-Amine TFA salt
4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
4-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C19H23N3O7 | [MOL File]
1957236-10-0.mol | [Molecular Weight]
405.4 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-997. DOI:10.1016/j.immuni.2020.07.018 |
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