| Identification | Back Directory | [Name]
dBET6 | [CAS]
1950634-92-0 | [Synonyms]
dBET6
DBET6;DBET-6 ;DBET 6
(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)- | [Molecular Formula]
C42H45ClN8O7S | [MDL Number]
MFCD31692407 | [MOL File]
1950634-92-0.mol | [Molecular Weight]
841.37 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM)
Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM) | [form ]
A solid | [pka]
10.68±0.40(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity. | [Definition]
ChEBI: DBET6 is an organic molecular entity. | [Biological Activity]
dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC. | [target]
| Target | Value | BRD4
() | 14 nM |
| [storage]
Store at -20°C |
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