| Identification | Back Directory | [Name]
AC-ESMD-CHO | [CAS]
191338-87-1 | [Synonyms]
AC-ESMD-CHO
AC-ESMD-ALDEHYDE
AC-GLU-SER-MET-ASP-CHO
N-Acetyl-Glu-Ser-Met-Asp-al
AC-GLU-SER-MET-ASP-ALDEHYDE
ACETYL-GLU-SER-MET-ASPARTINAL
N-ACETYL-GLU-SER-MET-ASPARTINAL
GRANZYME B INHIBITOR (ALDEHYDE)
AC-GLU-SER-MET-ASP-ALDEHYDE (PSEUDO ACID)
Acetyl-glutamyl-serinyl-methionyl-aspartal
CASPASE-3 PROCESSING INHIBITOR II (ALDEHYDE)
CASPASE-3 PROCESSING ENZYME INHIBITOR II (ALDEHYDE) | [Molecular Formula]
C19H30N4O10S | [MDL Number]
MFCD01318859 | [MOL File]
191338-87-1.mol | [Molecular Weight]
506.53 |
| Chemical Properties | Back Directory | [Boiling point ]
1049.7±65.0 °C(Predicted) | [density ]
1.386±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
H2O: 1 mg/mL | [form ]
powder | [pka]
4.19±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2]. | [References]
[1] Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. DOI:10.1046/j.1525-1373.2000.22518.x
[2] Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65. DOI:10.1111/j.1742-4658.2007.05994.x |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
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