| Identification | Back Directory | [Name]
AC-IETD-CHO | [CAS]
191338-86-0 | [Synonyms]
AC-IETD-CHO
AC-IETD-ALDEHYDE
CASPASE 8 INHIBITOR 1
CASPASE-8 INHIBITOR I
AC-ILE-GLU-THR-ASP-CHO
GRANZYME B INHIBITOR II
IETD-CHO, CELL-PERMEABLE
AC-ILE-GLU-THR-ASP-ALDEHYDE
AC-ILE-GLU-THR-ASP-H (ALDEHYDE)
GRANZYME B INHIBITOR (ALDEHYDE)
N-Acetyl-Ile-Glu-Thr-Asp-al
CASPASE 6/CASPASE 8 INHIBITOR W-1
CASPASE-8 INHIBITOR I, CELL-PERMEABLE
GRANZYME B INHIBITOR II, CELL-PERMEABLE
N-ACETYL-ILE-GLU-THR-ASP-CHO (ALDEHYDE)
AC-ILE-GLU-THR-ASP-ALDEHYDE (PSEUDO ACID)
Acetyl-isoleucyl-glutamyl-threonyl-aspartal
CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)
CASPASE-3 PROCESSING ENZYME INHIBITOR I (ALDEHYDE)
ACETYL-L-ISOLEUCYL-L-GLUTAMYL-L-THREONYL-L-ASPART-1-AL
CASPASE-8 / CASPASE-3 PROCESSING ENZYME INHIBITOR (ALDEHYDE)
L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
AC-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-ILE-GLU-THR-ASP-CHO | [Molecular Formula]
C21H34N4O10 | [MDL Number]
MFCD01318858 | [MOL File]
191338-86-0.mol | [Molecular Weight]
502.52 |
| Hazard Information | Back Directory | [Uses]
Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2]. | [Biological Activity]
Cell permeable: yes''Primary Target
caspase-8''Product does not compete with ATP.''Reversible: yes | [References]
[1] Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17. DOI:10.1093/toxsci/58.1.109
[2] Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. DOI:10.1046/j.1525-1373.2000.22518.x |
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BOC Sciences
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