| Identification | Back Directory | [Name]
MAFP | [CAS]
188404-10-6 | [Synonyms]
MAFP
MAPF
Phosphonofluoridicacid
METHYL ARACHIDONYL FLUOROPHOSPHONATE
(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester
METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER
5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER
Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester
(5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene
MAPF, Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
(5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENYL-METHYL ESTER PHOSPHONOFLUORIDIC ACID
METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE
Phosphonofluoridic acid, P-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-, methyl ester | [EINECS(EC#)]
201-185-2 | [Molecular Formula]
C21H36FO2P | [MDL Number]
MFCD03095722 | [MOL File]
188404-10-6.mol | [Molecular Weight]
370.48 |
| Chemical Properties | Back Directory | [Boiling point ]
455.3±34.0 °C(Predicted) | [density ]
0.960±0.06 g/cm3(Predicted) | [RTECS ]
TA8108000 | [Fp ]
-16 °C | [storage temp. ]
-70°C | [solubility ]
DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension | [form ]
methyl acetate solution
| [color ]
Light yellow to yellow | [Sensitive ]
Air Sensitive |
| Hazard Information | Back Directory | [Uses]
(all-Z)-5,8,11,14-Eicosatetraenylphosphonofluoridic Acid Methyl Ester, is a cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. | [Definition]
ChEBI: Methyl Arachidonyl Fluorophosphonate is a phosphonic ester. | [Biological Activity]
Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH, anandamide amidase), the enzyme responsible for anandamide hydrolysis (IC 50 = 2.5 nM). Also binds irreversibly to CB 1 receptors (IC 50 = 20 nM). | [Biochem/physiol Actions]
MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A2, but not secretory phospholipase A2. MAFP is also a potent acetylcholinesterase inhibitor. |
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