| Identification | Back Directory | [Name]
DBCO-PEG4-amine | [CAS]
1840886-10-3 | [Synonyms]
DBCO-PEG2-amine TFA salt
DBCO-PEG4-amine TFA salt
Dibenz[b,f]azocine-5(6H)-butanamide, N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-γ-oxo- | [Molecular Formula]
C29H37N3O6 | [MOL File]
1840886-10-3.mol | [Molecular Weight]
523.63 |
| Chemical Properties | Back Directory | [Boiling point ]
784.1±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous Liquid | [pka]
15.14±0.46(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
NFJQULPXXATMFO-UHFFFAOYSA-N | [SMILES]
C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. | [Biological Activity]
DBCO-PEG4-amine is a PROTAC bridge and belongs to the PEG class. DBCO-PEG4-amine can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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Tags:1840886-10-3
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