Identification | Back Directory | [Name]
DBCO-PEG4-Acid | [CAS]
1537170-85-6 | [Synonyms]
DBCO-PEG4-Acid DBCO-PEG4-COOH ADIBO-PEG4-acid DBCO-PEG4-C2-acid Aurumpharma u63872 DBCO-CONH-PEG4-acid ADIBO-PEG4-acid 90% (HPLC) Dibenzocyclooctyne-PEG4-acid DBCO-PEG4-acid,DBCO-PEG4-COOH 4,7,10,13-Tetraoxa-16-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo- | [Molecular Formula]
C30H36N2O8 | [MDL Number]
MFCD22380749 | [MOL File]
1537170-85-6.mol | [Molecular Weight]
552.62 |
Chemical Properties | Back Directory | [Boiling point ]
839.7±65.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid or Viscous Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Yellow to Orange | [InChIKey]
LKSAMQQFMTVPKD-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O |
Hazard Information | Back Directory | [Description]
DBCO-PEG4-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG spacer adds hydrophilicity to the product to decrease aggregation. |
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Sigma-Aldrich
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