| Identification | Back Directory | [Name]
PD153035 HCl | [CAS]
183322-45-4 | [Synonyms]
CS-473
ZM 252868
ZM 252868 HCl
AG 1517, SU 5271
PD153035 (HCl salt)
PD153035 HCl (SU5271
AG1517 (Hydrochloride)
PD153035 HCl USP/EP/BP
SU-5271 (Hydrochloride)
ZM 252868 (Hydrochloride)
PD 153035 Hydrochloride >
PD153035 HCl (SU-5271, AG1517)
PD 153035 hydrochloride, >=98%
PD153035 Hydrochloride PD-153035
PD153035 Hydrochloride (ZM 252868
9-DIAMINO-2-ETHOXYACRIDINE LACTATE
SU-5271 (AG1517) HCl ,ZM 252868 HCl
PD 153035 Isethionate Salt
DISCONTINUED
PD 153035;SU 5271; AG-1517;PD-153035;SU5271; AG 1517
N-(3-BroMophenyl)-6,7-diMethoxyquinazolin-4-aMine hydrochloride
N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine Hydrochloride
6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, monohydrochloride
PD 153035;SU 5271; AG-1517;PD-153035;SU5271; AG 1517;ZM 252868; TYRPHOSTIN AG 1517
6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride PD153035 | [Molecular Formula]
C16H14BrN3O2.HCl | [MDL Number]
MFCD01074805 | [MOL File]
183322-45-4.mol |
| Hazard Information | Back Directory | [Uses]
PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM). | [Definition]
ChEBI: A hydrochloride obtained by combining PD-153035 with one equivalent of hydrochloric acid. | [Biological Activity]
PD153035 is apotent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR. | [Enzyme inhibitor]
This extraordinarily potent EGFR inhibitor (F.Wt. = 396.67 (as
hydrochloride); CAS 183322-45-4 (hydrochloride), 153436-54-5 (free
base); Solubility (25°C) : <1 mg/mL DMSO, <1 mg/mL Water), also known
systematically as N- (3-bromophenyl) -6,7-dimethoxyquinazolin-4-amine,
rapidly suppresses in vitro EGFR autophosphorylation (Ki = 5.2 pM; IC50 =
29 pM) and selectively blocks EGF-mediated cellular processes including
mitogenesis, early gene expression, and oncogenic transformation.
PD153035 exposure does not affect the expression of either EGF receptors
or HER2/neu. PD153035 causes dose-dependent growth inhibition of
EGF receptor-overexpressing cell lines at low micromolar concentrations,
and the IC50 values in monolayer cultures at less than 1 μM in most cell
lines tested. |
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