| Identification | Back Directory | [Name]
incb057643 | [CAS]
1820889-23-3 | [Synonyms]
INCB
CS-2906
incb057643
2H-1,4-Benzoxazin-3(4H)-one, 8-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-2,2,4-trimethyl-6-(methylsulfonyl)- | [Molecular Formula]
C20H21N3O5S | [MDL Number]
MFCD31657400 | [MOL File]
1820889-23-3.mol | [Molecular Weight]
415.46 |
| Chemical Properties | Back Directory | [Boiling point ]
787.7±60.0 °C(Predicted) | [density ]
1.370±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml | [form ]
A crystalline solid | [pka]
14.74±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
INCB-057643, is a novel, orally bioavailable BET inhibitor. | [in vivo]
Production of several cytokines, including IL-6, IL-10 and MIP-1α, is repressed by INCB-057643 in human and mouse whole blood stimulated ex vivo with LPS. Oral administration of INCB-057643 results in significant anti-tumor efficacy in xenograft models of AML, myeloma, and DLBCL. Additionally, combining INCB-057643 with standard of care agents used for the treatment of DLBCL including rituximab and bendamustine results in enhanced anti-tumor efficacy relative to that achieved with single agent therapies at doses that are well tolerated[1]. | [storage]
Store at -20°C |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|