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ChemicalBook--->CAS DataBase List--->1817735-38-8

1817735-38-8

1817735-38-8 Structure

1817735-38-8 Structure
IdentificationBack Directory
[Name]

Carboxy-PEG5-sulfonic acid
[CAS]

1817735-38-8
[Synonyms]

Carboxy-PEG5-sulfonic acid
[Molecular Formula]

C13H26O10S
[MDL Number]

MFCD29042367
[MOL File]

1817735-38-8.mol
[Molecular Weight]

374.4
Chemical PropertiesBack Directory
[density ]

1.299±0.06 g/cm3(Predicted)
[solubility ]

Soluble in Water
[pka]

1.34±0.50(Predicted)
Hazard InformationBack Directory
[Description]

Carboxy-PEG5-sulfonic acid is a PEG linker containing carboxylic acid and sulfonic acid. The terminal carboxylic acid can participate in reactions with primary amines in the presence of activators such as EDC and HATU. The sulfonic acid group can undergo esterification, halogenation and replacement reactions. The hydrophilic PEG linker increases solubility of a compound in aqueous media.
[Uses]

Carboxy-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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