| Identification | Back Directory | [Name]
Carboxy-PEG4-phosphonic acid | [CAS]
1623791-69-4 | [Synonyms]
Carboxy-PEG4-phosphonic acid
4,7,10,13-Tetraoxa-16-phosphahexadecanoic acid, 16,16-dihydroxy-, 16-oxide | [Molecular Formula]
C11H23O9P | [MDL Number]
MFCD30182021 | [MOL File]
1623791-69-4.mol | [Molecular Weight]
330.27 |
| Chemical Properties | Back Directory | [Boiling point ]
545.5±60.0 °C(Predicted) | [density ]
1.324±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
2.14±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Carboxy-PEG4-phosphonic acid is a PEG linker with a carboxylic acid and phosphonic acid ends groups. The carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media. | [Uses]
Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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