| Identification | More | [Name]
TRIS(TRIMETHYLSILYL)PHOSPHITE | [CAS]
1795-31-9 | [Synonyms]
PHOSPHOROUS ACID TRIS(TRIMETHYLSILYL) ESTER
TRIS(TRIMETHYLSILYL)PHOSPHITE
Phosphorous acid, tristrimethylsilyl
Tris(trimethylsily)phosphite
Phosphorousacidtrimethylsilylester
TRIS(TRIMETHYLSILYL) PHOSPHITE 95%
TRIS(TRIMETHYLSILYL)PHOSPHITE 97+%
Phosphorous acid tri(trimethylsilyl) ester
Tris(trimethylsiloxy)phosphine | [Molecular Formula]
C9H27O3PSi3 | [MDL Number]
MFCD00015588 | [Molecular Weight]
298.54 | [MOL File]
1795-31-9.mol |
| Chemical Properties | Back Directory | [Boiling point ]
78-81 °C/8 mmHg (lit.) | [density ]
0.893 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.409(lit.)
| [Fp ]
>230 °F
| [form ]
Liquid | [color ]
Clear colorless | [Specific Gravity]
0.893 | [Water Solubility ]
Sparingly soluble in water. | [Hydrolytic Sensitivity]
8: reacts rapidly with moisture, water, protic solvents | [Sensitive ]
Air & Moisture Sensitive | [BRN ]
2043814 | [InChI]
InChI=1S/C9H27O3PSi3/c1-14(2,3)10-13(11-15(4,5)6)12-16(7,8)9/h1-9H3 | [InChIKey]
VMZOBROUFBEGAR-UHFFFAOYSA-N | [SMILES]
[Si](C)(C)(OP(O[Si](C)(C)C)O[Si](C)(C)C)C | [CAS DataBase Reference]
1795-31-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1760 | [WGK Germany ]
3
| [F ]
10-21 | [TSCA ]
No | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29319000 |
| Hazard Information | Back Directory | [Uses]
Tris(trimethylsilyl) Phosphite is used in the studies of bisphosphonic acids as effective inhibitor of glutamine synthetase, a promising approach for the discovery of novel drugs against tuberculosis. It also acts as a reagent in the preparation of substituted calix[4]arenes bearing one or two α-hydroxymethylphosphonic acid fragments at upper rim of macrocycle as inhibitors of glutathione S-transferase in vitro. | [Preparation]
By silylation of anhydrous phosphorous acid (dried by repeated azeotropic evaporation of a solution in THF with dry benzene) with excess Chlorotrimethylsilane and excess Triethylamine in dimethoxyethane, toluene, or Et2O-THF, followed by evaporation of the solvent and vacuum distillation of the residue. The residue, which contains a mixture of tris(trimethylsilyl) phosphite and bis(trimethylsilyl) phosphonate [HP(O)(OTMS)2], can also be heated with sodium (140 °C, 13-22 h), followed by vacuum distillation to obtain pure tris(trimethylsilyl) phosphite. | [storage]
Extremely hygroscopic; use in a fume hood. |
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