| Identification | Back Directory | [Name]
SAUCHINONE | [CAS]
177931-17-8 | [Synonyms]
SAUCHINONE
Sauchinone >=98% (HPLC)
Sauchinone, 98%, from Saururus chinensis (Lour. ) Baill
(5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one
(5aα,7α,8β,8aβ,14aS*,14bβ)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one
(5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro- 5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one
5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)- | [Molecular Formula]
C20H20O6 | [MDL Number]
MFCD08702698 | [MOL File]
177931-17-8.mol | [Molecular Weight]
356.37 |
| Chemical Properties | Back Directory | [Melting point ]
224-226℃ | [Boiling point ]
498.1±45.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Sauchinone is a lignan first isolated from the aerial parts of S. chinensis, a plant used in Asian medicine for its anti-inflammatory, anti-angiogenic, and anti-nociceptive activities. Sauchinone has numerous effects on isolated cells, including blocking NF-κB activation in LPS-stimulated macrophages, inducing heme oxygenase-1 transcription in endothelial cells, and attenuating oxidative-stress-induced damage in myoblasts. Sauchinone is extensively metabolized in vivo, but intraperitoneal administration significantly reduces myocardial infarct size induced by ischemia/reperfusion in mice. | [Biological Activity]
Sauchinone is an anti-inflammatory and antioxidant lignan isolated from Saururus chinensis a medical plant used for the treatment of feverjaundiceoedema and inflammatory disease in oriental folk medicine. Sauchinone inhibits LPS-inducible iNOS (NOS II)TNF-α and COX-2 expression in macrophages through suppression of IKBα phosphorylation. It appears th at sauchinone protects against myocardial ischemia/reperfusion injury by inhibition of p28 phosphorylation. |
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