| Identification | Back Directory | [Name]
Artemisinin-d3 | [CAS]
176652-07-6 | [Synonyms]
QHS-d3
Arteannuin-d3
Artemisine-d3
Artemisinin-d3
Huanghuahaosu-d3
(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6-dimethyl-9-(methyl-d3)-3,12-epox-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one | [Molecular Formula]
C15H22O5 | [MOL File]
176652-07-6.mol | [Molecular Weight]
282.332 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
156-157°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO: Slightly soluble,Methanol: Slightly soluble | [form ]
A solid | [CAS DataBase Reference]
176652-07-6 |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
Active antimalarial constituent of the tradional Chinese medicinal herb Artemisia annua L., Compositae, which has been known for almost 2000 years as Qinghao. Antimalarial | [Description]
Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day). Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner. It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria. | [storage]
Store at -20°C |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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Pharma Affiliates
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172-5066494 |
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http://m.is0513.com/ShowSupplierProductsList694812/0.htm |
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