| Chemical Properties | Back Directory | [Melting point ]
280-282 °C | [Boiling point ]
490.9±45.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 62.5 mg/mL (234.71 mM) | [form ]
Solid | [pka]
8.32±0.20(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Biological Activity]
Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation. | [in vivo]
Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets. | [target]
| Flk-1 < span> 9.3 μM (IC 50 ) | PDGFRβ 5 μM (IC 50 ) | | [storage]
Store at -20°C |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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