| Identification | Back Directory | [Name]
Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- | [CAS]
1664335-55-0 | [Synonyms]
Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- | [Molecular Formula]
C25H22FNO4 | [MDL Number]
MFCD32874094 | [MOL File]
1664335-55-0.mol | [Molecular Weight]
419.44 |
| Chemical Properties | Back Directory | [Boiling point ]
607.4±55.0 °C(Predicted) | [density ]
1.302±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.22±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1]. | [IC 50]
LPA1 Receptor: 1.7-14.5 nM (Kd) | [References]
[1] Jonathan Ellery, et al. Identification of Compounds Acting as Negative Allosteric Modulators of the LPA 1 Receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15. DOI:10.1016/j.ejphar.2018.05.040 |
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