| Identification | More | [Name]
6-Chloro-2-fluoropurine | [CAS]
1651-29-2 | [Synonyms]
2-fluoro-6-chloropurine
6-CHLORO-2-FLUORO-9H-PURINE
6-CHLORO-2-FLUOROPURINE
6-CHLORO-2-FLUORPURINE | [EINECS(EC#)]
634-083-5 | [Molecular Formula]
C5H2ClFN4 | [MDL Number]
MFCD02183557 | [Molecular Weight]
172.55 | [MOL File]
1651-29-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
162-163°C | [Boiling point ]
221.8±50.0 °C(Predicted) | [density ]
1.98±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml | [form ]
powder to crystal | [pka]
4.88±0.20(Predicted) | [color ]
White to Light yellow to Green | [InChI]
InChI=1S/C5H2ClFN4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11) | [InChIKey]
UNRIYCIDCQDGQE-UHFFFAOYSA-N | [SMILES]
N1C2C(=NC(F)=NC=2Cl)NC=1 | [CAS DataBase Reference]
1651-29-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S39:Wear eye/face protection . | [WGK Germany ]
3 | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Description]
6-Chloro-2-fluoropurine is a heterocyclic building block.1,2 It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro.1 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.2 | [Chemical Properties]
Beige solid | [Uses]
6-Chloro-2-fluoropurine is used as a reagent in the synthesis of several organic compounds including that of 2''-Fluoro-3''-Hydroxymethyl-5''-deoxythreosyl phosphonic acid nucleoside analogues which may potentially act as antiviral agents. It is also used in the synthesis of 2'',5'',5''-trifluoro-3''-hydroxy-apiosyl nucleoside phosphonic acid analogues which may possess potent anti-HCMV properties. |
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