| Identification | More | [Name]
(R)-4-Boc-2-methylpiperazine | [CAS]
163765-44-4 | [Synonyms]
1-PIPERAZINECARBOXYLIC ACID, 3-METHYL-, 1,1-DIMETHYLETHYL ESTER, (3R)-
(3R)-1-BOC-3-METHYLPIPERAZINE
4-BOC-2-(R)-METHYL-PIPERAZINE
(R)-1-BOC-3-METHYLPIPERAZINE
(R)-1-N-BOC-3-METHYLPIPERAZINE
(R)-1-TERT-BUTOXYCARBONYL-3-METHYLPIPERAZINE
(R)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(R)-4-BOC-2-METHYLPIPERAZINE
(R)-4-N-BOC-2-METHYLPIPERAZINE
(R)-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(R)-N4-BOC-2-METHYLPIPERAZINE
(R)-N-BOC-2-METHYLPIPERAZINE
TERT-BUTYL (R)-3-METHYL-1-PIPERAZINECARBOXYLATE
(R)-3-Methyl-1-Boc-piperazine
(R)-4-N-Boc-2-methylpiperazine
(R )-4-N-Boc-2-methyl piperazine
(S)-1-BOC-3-METHYL-PIPERAZINE,(R)-1-Boc-3-methylpiperazine
(R)-2-Methylpiperazine, N4-BOC protected
(R)-1-Boc-3-methylpiperazine, tert-Butyl (R)-3-methyl-1-piperazinecarboxylate
(R)-4-Boc-2-piperazinecarboxylic acid | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD02683205 | [Molecular Weight]
200.28 | [MOL File]
163765-44-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
40-45 °C
| [Boiling point ]
268.7±15.0 °C(Predicted) | [density ]
0.997±0.06 g/cm3(Predicted) | [Fp ]
223 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Crystalline Powder | [pka]
8.52±0.40(Predicted) | [color ]
White | [optical activity]
[α]/D +16±2°, c = 1 in dioxane | [InChIKey]
FMLPQHJYUZTHQS-MRVPVSSYSA-N | [CAS DataBase Reference]
163765-44-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [WGK Germany ]
3
| [F ]
10-34 | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid | [Synthesis]
To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).
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