| Identification | More | [Name]
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline | [CAS]
16357-59-8 | [Synonyms]
1-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE
2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECARBOXYLIC ACID ETHYL ESTER
2-ETHOXY-1(2H)-QUINOLINECARBOXYLIC ACID ETHYL ESTER
2-ETHOXY-1-ETHOXYCARBONYL-1,2-DIHYDROQUINOLINE
EEDQ
ETHYL 1,2-DIHYDRO-2-ETHOXY-1-QUINOLINECARBOXYLATE
ETHYL 1,2-DIHYDRO-2-ETHOXYQUINOLINE-1-CARBOXYLATE
ETHYL 2-ETHOXY-1,2-DIHYDRO-1-QUINOLINECARBOXYLATE
LABOTEST-BB LT00440890
N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE
2-ethoxy-1(2h)-quinolinecarboxylicaciethylester
EEDQ~N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
ethyl N-(2-ethoxy-1,2-dihydroquinoline)carboxylate
EEDQ (1-ETHOXY-CARBONYL-2-ETHOXY-1,2
EEDQ, 99+%, (2-ETHOXY-1-ETHOXYCARBONYL-1 ,2-DIHYDROQUINOLINE)
N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE 99% ( EEDQ)
Eedq(2-Ethoxy-1-Ethoxycarbonyl-1,2-Dihydroquinoline)
1,2-Dihydro-2-ethoxy-1-quinolinecarboxylicacidester
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, 99+%
1(2H)-Quinolinecarboxylic acid, 2-ethoxy-, ethyl ester | [EINECS(EC#)]
240-418-2 | [Molecular Formula]
C14H17NO3 | [MDL Number]
MFCD00006703 | [Molecular Weight]
247.29 | [MOL File]
16357-59-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White to pale yellow solid | [Melting point ]
62-67 °C(lit.) | [Boiling point ]
125-128 °C (0.1 mmHg) | [density ]
1.1173 (rough estimate) | [refractive index ]
1.5300 (estimate) | [Fp ]
125-128°C/0.1mm | [storage temp. ]
2-8°C | [form ]
Crystalline Powder | [pka]
-1.27±0.40(Predicted) | [color ]
White to beige | [Water Solubility ]
insoluble | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC,T | [Merck ]
14,3518 | [BRN ]
533048 | [CAS DataBase Reference]
16357-59-8(CAS DataBase Reference) | [EPA Substance Registry System]
16357-59-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R38:Irritating to the skin.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
VB2010000
| [F ]
9-21 | [TSCA ]
Yes | [HS Code ]
29334990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to pale yellow solid | [Uses]
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline is an irreversible membrane-bound receptor antagonist. It is used in synthetic chemistry, discovery, process R&D. It also acts as coupling reagents. | [Uses]
In the synthesis of peptides. | [Uses]
Peptide condensing agent with little or no racemization. Amidation coupling reagent. | [Purification Methods]
Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.] |
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