| Identification | More | [Name]
5-Chloro-2-nitroaniline | [CAS]
1635-61-6 | [Synonyms]
2-AMINO-4-CHLORO-NITROBENZENE
5-CHLORO-2-NITROANILINE
5-CHLORO-2-NITROBENZENAMINE
TIMTEC-BB SBB003828
5-chloro-2-nitro-benzenamin
Benzenamine, 5-chloro-2-nitro-
2-NITRO-5-CHLOROANILINE
5-Chlor-2-nitroanilin
5-CHLORO-2-NITROANILINE 99+%
2-Amino-4-chloro-1-nitrobenzene
5-Chloro-2-nitrophenylamine
5-Chloro-2-nitroaniline ,98% | [EINECS(EC#)]
216-661-5 | [Molecular Formula]
C6H5ClN2O2 | [MDL Number]
MFCD00007776 | [Molecular Weight]
172.57 | [MOL File]
1635-61-6.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to orange powder | [Melting point ]
125-129 °C (dec.)(lit.)
| [Boiling point ]
200°C (rough estimate) | [density ]
1.5610 (rough estimate) | [refractive index ]
1.5870 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Chloroform, Methanol | [form ]
Liquid | [pka]
-1.46±0.25(Predicted) | [color ]
Clear colorless to light yellow | [Detection Methods]
GC,NMR | [BRN ]
2210201 | [InChIKey]
ZCWXYZBQDNFULS-UHFFFAOYSA-N | [CAS DataBase Reference]
1635-61-6(CAS DataBase Reference) | [Storage Precautions]
Air sensitive |
| Questions And Answer | Back Directory | [Description]
2-Nitro-5-chloroaniline is an important pharmaceutical and veterinary drug intermediate. It has been applied in the upgraded product of veterinary drug albendazole-fenbendazole, and has a broad market prospect. | [Preparation]
Add 2.46mol of 2,4-dichloronitrobenzene, 7.72mol of toluene to a 3L autoclave, seal the autoclave, replace the air with nitrogen, then pass in 14.1mol of liquid ammonia, increase the temperature to 160℃, continue the reaction for 8h, and then lower the temperature to 40℃, drain the excess ammonia gas, open the kettle, add the obtained solid-liquid mixture to 800mL of water, continue to cool to 10℃, filter, add the resulting filter cake to the water, continue beating and filtering, the obtained solid is crystallized with methanol to obtain 388g , yield 91.2%, the purity of the liquid phase external standard is 99.5%. |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N,T | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2237 6.1/PG 3
| [WGK Germany ]
3
| [F ]
9-23 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214210 |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
Fenbendazole-->6-CHLOROQUINOXALINE-->2,3,6-TRICHLOROQUINOXALINE-->6-CHLORO-2,3-DIOXO-1,2,3,4-TETRAHYDROQUINOXALINE-->4-FLUORO-2-NITROBENZONITRILE-->4-Chloro-o-phenylenediamine-->2-Amino-5-chlorobenzenesulfonamide-->Hoechst 33342-->3,4-DiaMinodiphenyl ether-->5-Chloro-2-nitrophenol-->5-(4-BENZYLPIPERAZINO)-2-NITROANILINE-->2-NITRO-5-PYRROLIDIN-1-YL-PHENYLAMINE-->Benzenamine, 5-[(4-methylphenyl)thio]-2-nitro--->Carbamic acid, N-(5-chloro-2-nitrophenyl)-N-methyl-, 1,1-dimethylethyl ester-->(5-CHLORO-2-NITROPHENYL)HYDRAZINE-->2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol |
| Hazard Information | Back Directory | [Chemical Properties]
yellow to orange powder | [Uses]
5-Chloro-2-nitroaniline is a useful synthetic intermediate. It can be used as a reagent to synthesize benzamide derivatives as histone deacetylase inhibitors. It is an intermediate used to synthesize 1-Nitro Febantel a Febantel impurity. | [Application]
5-Chloro-2-nitroaniline was used in the synthesis of 5-(4-substituted piperazin-1-yl)-2-nitroanilines and 5-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates.
The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. | [General Description]
The coupling of divinylbenzene cross-linked polystyrene with 5-chloro-2-nitroaniline followed by oxidative decyanation afforded benzophenone. |
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