| Identification | More | [Name]
Isosorbide 5-mononitrate | [CAS]
16051-77-7 | [Synonyms]
1,4:3,6-DIANHYDRO-D-GLUCITOL 5-MONONITRATE
5-ISOSORBIDE MONONITRATE
CORANGIN
ELAN
ELANTAN
IMDUR
IS-5-MN
ISOSORBIDE 5-MONONITRATE
ISOSORBIDE 5-NITRATE
ISOSORBIDE MONONITRATE
MONOCEDOCARD
MONOCLAIR
MONOSORB
1,4:3,6-dianhydro-,5-nitrate,d-glucito
1,4:3,6-dianhydro-d-glucito5-nitrate
1,4:3,6-dianhydro-d-glucitol5-nitrate
5-ismn
ahr4698
bm22-145
Ososoribide-5-mononitrate | [EINECS(EC#)]
240-197-2 | [Molecular Formula]
C6H9NO6 | [MDL Number]
MFCD00143462 | [Molecular Weight]
191.14 | [MOL File]
16051-77-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
88-93 °C
| [alpha ]
170 º (c=1, EtOH) | [Boiling point ]
326.86°C (rough estimate) | [density ]
1.5784 (rough estimate) | [refractive index ]
145 ° (C=5, H2O) | [storage temp. ]
-20°C Freezer | [solubility ]
Undiluted isosorbide mononitrate is freely soluble in water, in acetone, in ethanol (96 per cent) and in methylene chloride. The solubility of the diluted product depends on the diluent and its concentration. | [form ]
Solid | [pka]
13.09±0.40(Predicted) | [color ]
White to Off-White | [Water Solubility ]
soluble | [Usage]
A metabolite of Isosorbide Dinitrate. Used as an antianginal | [Merck ]
5225 | [InChIKey]
YWXYYJSYQOXTPL-SLPGGIOYSA-N | [CAS DataBase Reference]
16051-77-7(CAS DataBase Reference) | [EPA Substance Registry System]
16051-77-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi-F,Xi,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R11:Highly Flammable. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking .
S15:Keep away from heat . | [RIDADR ]
3251 | [RTECS ]
LZ4386500 | [HazardClass ]
4.1 | [HS Code ]
2932999000 | [Toxicity]
LD50 oral in rat: 2010mg/kg |
| Hazard Information | Back Directory | [General Description]
ISOSORBIDE-5-MONONITRATE(16051-77-7) is a crystalline solid. ISOSORBIDE-5-MONONITRATE(16051-77-7) is very flammable and may be toxic by ingestion. | [Reactivity Profile]
The dinitrate, a heart drug, can detonate when dry, but is non explosive with 30% of water [J. Haz.. Mater., 1992, 32(1), 87]. The mononitrate would be expected to be less reactive. | [Air & Water Reactions]
Highly flammable. | [Health Hazard]
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. | [Fire Hazard]
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished. | [Chemical Properties]
white to light yellow crystal powde | [Uses]
A metabolite of Isosorbide Dinitrate. Used as an antianginal | [Uses]
antidepressant, 5HT reuptake inhibitor | [Definition]
ChEBI: Isosorbide mononitrate is a nitrate ester and a glucitol derivative. It has a role as a nitric oxide donor and a vasodilator agent. | [Brand name]
Imdur (Schering-Plough); Ismo (Dr. Reddy’s);
Monoket (Schwarz Pharma)
. | [Clinical Use]
Vasodilator:
Treatment and prophylaxis of angina
Adjunct in congestive heart failure | [Drug interactions]
Potentially hazardous interactions with other drugs
Avanafil: hypotensive effect significantly enhanced -
avoid.
Levosimendan: possible severe hypotension.
Riociguat: avoid concomitant use due to risk of
hypotension.
Sildenafil: hypotensive effect significantly enhanced
- avoid.
Tadalafil: hypotensive effect significantly enhanced
- avoid.
Vardenafil: hypotensive effect significantly enhanced
- avoid. | [Metabolism]
Unlike isosorbide dinitrate, isosorbide mononitrate does
not undergo first-pass hepatic metabolism. Isosorbide
mononitrate is taken up by smooth muscle cells of blood
vessels and the nitrate group is cleaved to inorganic
nitrite and then to nitric oxide. Isosorbide mononitrate is
metabolised to inactive metabolites, including isosorbide
and isosorbide glucuronide | [storage]
Store at -20°C |
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