| Identification | More | [Name]
5-Chlorovaleryl chloride | [CAS]
1575-61-7 | [Synonyms]
5-CHLORO-N-VALEROYL CHLORIDE
5-CHLOROPENTANOYL CHLORIDE
5-CHLOROVALEROYL CHLORIDE
5-CHLOROVALERYL CHLORIDE
D-CHLOROVALEROYL CHLORIDE
DELTA-CHLOROVALEROYL CHLORIDE
PENTANOYL CHLORIDE, 5-CHLORO-
5-chloro-pentanoylchlorid
5-chloro-valerylchlorid
5-Chlorovaleryl
5-CHLOROVALERYL CHLORIDE CVC
5-Chlorvalerylchlorid
5-Chlorovaleric acid chloride | [EINECS(EC#)]
216-403-1 | [Molecular Formula]
C5H8Cl2O | [MDL Number]
MFCD00000758 | [Molecular Weight]
155.02 | [MOL File]
1575-61-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to slightly yellow liquid | [Boiling point ]
38-39 °C0.15 mm Hg(lit.)
| [density ]
1.206 g/mL at 20 °C
| [refractive index ]
n20/D 1.464(lit.)
| [Fp ]
195 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
Acetonitrile (Slightly), Chloroform (Sparingly) | [form ]
Liquid | [color ]
Clear colorless to slightly yellow | [Specific Gravity]
1.200 | [PH]
<7 (H2O, 20℃) | [explosive limit]
2.0-10.2%(V) | [Water Solubility ]
reacts | [Sensitive ]
Moisture Sensitive | [BRN ]
1745182 | [Stability:]
Corrosive, Moisture Sensitive | [InChIKey]
SVNNWKWHLOJLOK-UHFFFAOYSA-N | [CAS DataBase Reference]
1575-61-7(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Description]
5-Chlorovaleryl chloride is an important synthetic intermediate of pyrazole herbicides. 5-Chloropentanoyl chloride is used as the raw material of 1,1,7-trichloro-1-hepten-3-one, and then the third-generation pyrazole herbicides can be synthesized. Pyrazole herbicides have the characteristics of ultra-efficient herbicidal activity, high selectivity, extremely low mammalian toxicity and good environmental characteristics, and have become a hot spot in the research and development of herbicides in the world in recent years. |
| Safety Data | Back Directory | [Hazard Codes ]
C,T | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R23:Toxic by inhalation. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
1
| [RTECS ]
YV9108000
| [F ]
10-19-21 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159000 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless to slightly yellow liquid | [Uses]
5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals. | [Application]
5-Chlorovaleryl chloride is an important medicine and pesticide intermediate. It is pharmaceutically mainly for the manufacture of the medicine Cilostazole (Cilostazol) for anti-platelet aggregation, protection of vascular endothelial cells, and atherosclerosis.5-Chlorovaleryl Chloride is also for the production of paddy rice New-type wide-spectrum weedicide pyraclonil (Pyraclonil).
| [General Description]
5-Chlorovaleroyl chloride is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals. | [Flammability and Explosibility]
Notclassified | [Synthesis]
In the existing process, producing 5-Chlorovaleryl chloride using 1,4-dichlorobutane as raw material requires a three-step reaction. First, 1,4-dichlorobutane and sodium cyanide solution are combined to form 5-chlorovaleronitrile. Then, the prepared 5-chlorovaleronitrile is hydrolyzed in concentrated hydrochloric acid to form 5-chlorovaleric acid. Finally, 5-chlorovaleronitrile reacts with thionyl chloride to generate 5-chlorovaleryl chloride.
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