| Identification | More | [Name]
Cysteamine hydrochloride | [CAS]
156-57-0 | [Synonyms]
2-AMINOETHANE-1-THIOL HYDROCHLORIDE
2-AMINOETHANETHIOL HCL
2-AMINOETHANETHIOL HYDROCHLORIDE
2-AMINOETHANOTHIOL HYDROCHLORIDE
2-AMINOETHYL MERCAPTAN HYDROCHLORIDE
2-MERCAPTOETHYLAMINE HCL
2-MERCAPTOETHYLAMINE HYDROCHLORIDE
BETA-MERCAPTOETHYLAMINE HYDROCHLORIDE
B-MERCAPTOETHYLAMINE HYDROCHLORIDE
CYSTEAMINE HCL
CYSTEAMINE HYDROCHLORIDE
CYSTEAMINIUM CHLORIDE
DECARBOXYCYSTEINE HCL
DECARBOXYCYSTEINE HYDROCHLORIDE
Mercaptamine hydrochloride
mercaptoethylammonium chloride
THIOETHANOLAMINE HYDROCHLORIDE
2-amino-ethanethiohydrochloride
2-Aminoethylmercaptarhydrochloride
2-mercapto-ethylaminhydrochloride | [EINECS(EC#)]
205-858-1 | [Molecular Formula]
C2H8ClNS | [MDL Number]
MFCD00012904 | [Molecular Weight]
113.61 | [MOL File]
156-57-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
67-71 °C
| [Boiling point ]
238.5℃[at 101 325 Pa] | [density ]
0.75
| [vapor pressure ]
5.333Pa at 25℃ | [refractive index ]
1.6100 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 1 m at 20 °C, clear, colorless
| [form ]
Crystalline Powder or Pellets | [color ]
White | [PH]
3.3-5.0 (400g/l, H2O, 20℃) | [Stability:]
Stable, but hygroscopic. Incompatible with strong oxidizing agents. | [biological source]
synthetic (organic) | [Water Solubility ]
VERY SOLUBLE | [Sensitive ]
Hygroscopic | [Usage]
Used as an antioxidant and in radiation therapy | [λmax]
λ: 280 nm Amax: ≤0.3 | [Merck ]
14,2779 | [BRN ]
3590083 | [InChIKey]
OGMADIBCHLQMIP-UHFFFAOYSA-N | [LogP]
-2.14 at 25℃ | [CAS DataBase Reference]
156-57-0(CAS DataBase Reference) | [EPA Substance Registry System]
156-57-0(EPA Substance) | [Absorption]
cut-off at 270nm in H2O at 1M |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3335 | [WGK Germany ]
3
| [RTECS ]
KJ0200000
| [F ]
1-3-10-13 | [TSCA ]
Yes | [HS Code ]
29309070 | [Toxicity]
LD50 orally in Rabbit: 642 mg/kg |
| Hazard Information | Back Directory | [Hazard]
Toxic by inhalation and ingestion. | [Description]
Cysteamine is a stable aminothiol with radioprotective activities.1 It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner.1,2 Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects.2 In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts.3 Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.4 | [Chemical Properties]
White Solid | [Uses]
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
| [General Description]
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. | [Biochem/physiol Actions]
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles. | [Synthesis]
In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.
| [Purification Methods]
Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.] |
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