| Identification | Back Directory | [Name]
Nebivolol hydrochloride | [CAS]
152520-56-4 | [Synonyms]
D06622
Lobivon
Nebilet
Nebilox
R-67555
Bystolic
Narbivolol
NEBIVOLOL HC
Nebivalate HCl
Nebivolol (Bystolic)
Nebivolol hydrochloride
RAC NEBIVOLOL, HYDROCHLORIDE
Nebivolol hydrochloride (usan)
Nebivolol hydrochloride, >=98%
NEBIVOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE)
a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
(aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-(±)- | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C22H26ClF2NO4 | [MDL Number]
MFCD07357273 | [MOL File]
152520-56-4.mol | [Molecular Weight]
441.9 |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Powder | [Melting point ]
220-222°C | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [color ]
white to off-white | [Merck ]
14,6432 |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Powder | [Uses]
A ?-Adrenergic blocker. Used as an antihypertensive | [Uses]
Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM | [Biological Activity]
Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo . | [Definition]
ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride. | [Biochem/physiol Actions]
Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods. | [storage]
Desiccate at RT |
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