| Identification | More | [Name]
4-Difluoromethoxy-3-hydroxybenzaldehyde | [CAS]
151103-08-1 | [Synonyms]
3-Hydroxy-4-diflouromethylbenzaldehyde
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE
4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
4-(Difluoromethoxy)-3-hydroxybenzaldehyde97% | [EINECS(EC#)]
687-745-0 | [Molecular Formula]
C8H6F2O3 | [MDL Number]
MFCD04406687 | [Molecular Weight]
188.13 | [MOL File]
151103-08-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
85-90°C | [Boiling point ]
280.6±35.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.85±0.35(Predicted) | [color ]
White | [InChI]
InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H | [InChIKey]
ZLIKNROJGXXNJG-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=C(OC(F)F)C(O)=C1 | [CAS DataBase Reference]
151103-08-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
2913000090 |
| Hazard Information | Back Directory | [Description]
4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude[1]. | [Chemical Properties]
4-Difluoromethoxy-3-hydroxybenzaldehyde is white powder
| [Uses]
4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.
| [References]
[1] YAN LIN. Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product[J]. Research on Chemical Intermediates, 2012. DOI:10.1007/s11164-012-0823-3. |
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