Identification | More | [Name]
4-Methylsulfonylphenol | [CAS]
14763-60-1 | [Synonyms]
4-METHANESULFONYL-PHENOL 4-(METHYLSULFONYL)PHENOL 4-METHYLSULPHONYLPHENOL 4-(methylsulfonyl)-pheno 4-Hydroxyphenyl methyl sulfone 4-hydroxyphenylmethylsulfone p-(methylsulfonyl)-pheno p-(Methylsulfonyl)phenol Phenol, 4-(methylsulfonyl)- Phenol, p-(methylsulfonyl)- p-Hydroxyphenyl methyl sulfone p-hydroxyphenylmethylsulfone 4-METHANESULPHONYLPHENOL 4-METHYLSULPHONYLPHENOL 95% 4-Methylsulphonylphenol,95% 4-Mesylphenol | [EINECS(EC#)]
217-420-7 | [Molecular Formula]
C7H8O3S | [MDL Number]
MFCD00047806 | [Molecular Weight]
172.2 | [MOL File]
14763-60-1.mol |
Chemical Properties | Back Directory | [Appearance]
Tan to pink-brown powder | [Melting point ]
90-95 °C
| [Boiling point ]
272.52°C (rough estimate) | [density ]
1.3692 (rough estimate) | [refractive index ]
1.5151 (estimate) | [RTECS ]
SM1530000 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO, Methanol | [form ]
Powder | [pka]
pK1:7.83 (25°C) | [color ]
Tan to pink-brown | [Water Solubility ]
slight | [BRN ]
1866322 | [LogP]
0.886 (est) | [CAS DataBase Reference]
14763-60-1(CAS DataBase Reference) | [NIST Chemistry Reference]
4-(Methylsulfonyl)phenol(14763-60-1) |
Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
29309090 |
Hazard Information | Back Directory | [Chemical Properties]
Tan to pink-brown powder | [Uses]
4-(Methylsulfonyl)phenol is a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Also a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators. | [Reactions]
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%). |
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