| Identification | More | [Name]
5-BENZYLOXYGRAMINE | [CAS]
1453-97-0 | [Synonyms]
5-BENZYLOXY-3-(DIMETHYLAMINOMETHYL)INDOLE
5-BENZYLOXYGRAMINE
N-[[5-(BENZYLOXY)-1H-INDOL-3-YL]METHYL]-N,N-DIMETHYLAMINE
TIMTEC-BB SBB003021
5-benzyloxy-N,N-dimethylamino-3-methylindole
5-BENZYLOXYGRAMINE CRYSTALLINE
5-Benzyloxygramine, 99+%
3-(Dimethylaminomethyl)-5-(benzyloxy)-1H-indole
5-Benzyloxy-3-(dimethylaminomethyl)-1H-indole | [EINECS(EC#)]
215-927-8 | [Molecular Formula]
C18H20N2O | [MDL Number]
MFCD00005631 | [Molecular Weight]
280.36 | [MOL File]
1453-97-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white fine crystalline powder | [Melting point ]
137-139 °C(lit.) | [Boiling point ]
442.3±35.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (891.71 mM; Need ultrasonic) | [form ]
Solid | [pka]
16.63±0.30(Predicted) | [color ]
Off-white to light yellow | [CAS DataBase Reference]
1453-97-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [Hazard Note ]
Irritant |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white fine crystalline powder | [Uses]
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001 | [References]
[1] Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141. DOI:10.1021/acs.jmedchem.9b01913 |
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