| Identification | More | [Name]
PYRIDINE-2-CARBOXAMIDE | [CAS]
1452-77-3 | [Synonyms]
2-PICOLINAMIDE
2-PYRIDINECARBOXAMIDE
PICOLINAMIDE
PYRIDINE-2-CARBOXAMIDE
PYRIDINE-2-CARBOXYLIC ACID AMIDE
TIMTEC-BB SBB008128
2-Carbamoylpyridine
alpha-Picolinamide
alpha-Picolinic acid amide
Picolinic acid amide
Picolinoylamide
Pyridine-2-carboxylicamide
Picolinamide ,98% | [EINECS(EC#)]
215-921-5 | [Molecular Formula]
C6H6N2O | [MDL Number]
MFCD00023483 | [Molecular Weight]
122.12 | [MOL File]
1452-77-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white solid | [Uses]
Picolinamide was used as template in preparation of molecular imprinting polymer. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO4. | [Uses]
A nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene. | [Definition]
ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of picolinic acid. | [Biological Activity]
picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor.parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer. | [Biochem/physiol Actions]
Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. Picolinamide acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates. | [in vitro]
the pathway of oxidation of picolinamide by a gram-negative rod has been elucidated. results showed that under high ph conditions, whole cells could release 2,5-dihydroxypyridine into culture supernatants. moreover, sodium arsenite was able to cause whole cells to accumulate 6-hydroxypicolinate in the culture media. in addition, whole cells were found to oxidize picolinamide, without lag. it was also found that cell-free extracts could convert picolinamide into picolinate, and hydroxylate picolinate into 6-hydroxypicolinate [1]. | [in vivo]
picolinamide was used in a previous study to evaluate the possibility that the inhibition of na+/phosphate cotransport might be associated with the inhibition of nad hydrolyzing enzymes. results showed that the overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), could inhibit na+/phosphate cotransport by isolated renal brush border membrane vesicles. similar to nicotinamide, the inhibition caused by picolinamide occurred in thyroparathyroidectomized rats, was specific for na+/phosphate cotransport. unlike nicotinamide, there was only a small 1.5-fold increase in renal cortical nad content after picolinamide treatment [2]. | [References]
[1] c. g. orpin,m. knight, and w. c. evans. the bacterial oxidation of picolinamide, a photolytic product of diquatbiochem j. 1972 may; 127(5): 819–831.
[2] campbell pi, al-mahrouq ha,abraham mi,kempson sa. specific inhibition of rat renal na+/phosphate cotransport by picolinamide. j pharmacol exp ther.1989 oct;251(1):188-92. |
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